Insulin Mixtard 50 Novolet may be available in the countries listed below.
Insulin Injection, Biphasic Isophane human (a derivative of Insulin Injection, Biphasic Isophane) is reported as an ingredient of Insulin Mixtard 50 Novolet in the following countries:
International Drug Name Search
Delpral may be available in the countries listed below.
Tiapride hydrochloride (a derivative of Tiapride) is reported as an ingredient of Delpral in the following countries:
International Drug Name Search
Sivacor may be available in the countries listed below.
Simvastatin is reported as an ingredient of Sivacor in the following countries:
International Drug Name Search
Chemmart Clomipramine may be available in the countries listed below.
Clomipramine hydrochloride (a derivative of Clomipramine) is reported as an ingredient of Chemmart Clomipramine in the following countries:
International Drug Name Search
Tandamol may be available in the countries listed below.
Paracetamol is reported as an ingredient of Tandamol in the following countries:
International Drug Name Search
Hydrochlorothiazide is reported as an ingredient of Moexipril Hydrochloride and Hydrochlorthiazide in the following countries:
Moexipril hydrochloride (a derivative of Moexipril) is reported as an ingredient of Moexipril Hydrochloride and Hydrochlorthiazide in the following countries:
International Drug Name Search
Verapamil HCl Sandoz may be available in the countries listed below.
Verapamil hydrochloride (a derivative of Verapamil) is reported as an ingredient of Verapamil HCl Sandoz in the following countries:
International Drug Name Search
Relieving symptoms of sinus congestion, runny nose, sneezing, itchy nose or throat, itchy or watery eyes, cough due to colds, upper respiratory infections, or allergies. It may also be used for other conditions as determined by your doctor.
Dextromethorphan/Phenylephrine Syrup is a decongestant, antihistamine, and cough suppressant combination. The decongestant works by constricting blood vessels and reducing swelling in the nasal passages. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing. The cough suppressant works in the brain to help decrease the cough reflex to reduce a dry cough.
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with Dextromethorphan/Phenylephrine Syrup. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
Some MEDICINES MAY INTERACT with Dextromethorphan/Phenylephrine Syrup. Tell your health care provider if you are taking any other medicines, especially any of the following:
This may not be a complete list of all interactions that may occur. Ask your health care provider if Dextromethorphan/Phenylephrine Syrup may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Use Dextromethorphan/Phenylephrine Syrup as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Dextromethorphan/Phenylephrine Syrup.
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Anxiety; constipation; diarrhea; dizziness; drowsiness; dry mouth, nose, or throat; excitability; headache; loss of appetite; nausea; trouble sleeping; upset stomach; vomiting; weakness.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating or inability to urinate; fast or irregular heartbeat; fever, chills, or persistent sore throat; hallucinations; loss of coordination; mental or mood changes (eg, depression); nervousness; seizures; severe dizziness, drowsiness, light-headedness, or headache; severe dryness of mouth, nose, and throat; severe or persistent trouble sleeping; shortness of breath; tremor; unusual bruising or bleeding; unusual tiredness or weakness; vision problems (eg, double vision, blurred vision).
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; flushing; hallucinations; mental or mood changes; muscle spasms; seizures; severe dizziness, light-headedness, or headache; severe drowsiness; trouble breathing; unusually fast, slow, or irregular heartbeat; vomiting.
Store Dextromethorphan/Phenylephrine Syrup at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Dextromethorphan/Phenylephrine Syrup out of the reach of children and away from pets.
This information is a summary only. It does not contain all information about Dextromethorphan/Phenylephrine Syrup. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Generic Name: galantamine (ga LAN ta meen)
Brand Names: Razadyne, Razadyne ER
Galantamine improves the function of nerve cells in the brain. It works by preventing the breakdown of a chemical called acetylcholine (ah see til KO leen). People with dementia usually have lower levels of this chemical, which is important for the processes of memory, thinking, and reasoning.
Galantamine is used to treat mild to moderate dementia caused by Alzheimer's disease.
Galantamine may also be used for purposes other than those listed in this medication guide.
Before taking galantamine, tell your doctor if you are allergic to any drugs, or if you have urination problems, heart disease, a heart rhythm disorder, stomach ulcers or bleeding, a seizure disorder, kidney disease, liver disease, or asthma.
There are many other medicines that can interact with galantamine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
If you need to have any type of surgery, tell the surgeon ahead of time that you are taking galantamine. You may need to stop using the medicine for a short time.
Before taking galantamine, tell your doctor if you are allergic to any drugs, or if you have:
urination problems;
heart disease or a heart rhythm disorder;
a history of stomach ulcer or bleeding;
seizures or epilepsy;
a history of asthma or obstructive pulmonary disease.
If you have any of these conditions, you may need a dose adjustment or special tests to safely take galantamine.
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get the best results from this medication.
Galantamine is usually taken once or twice a day with a meal. You may also take the medication without food. Follow your doctor's instructions.
The liquid form of this medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.
Measure the liquid using only the special dose-measuring device provided. Empty the medicine into 3 to 4 ounces of any non-alcoholic beverage. Stir this mixture and drink all of it right away. Rinse the dose-measuring device with water after each use.
If you need to have any type of surgery, tell the surgeon ahead of time that you are taking galantamine. You may need to stop using the medicine for a short time.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
Overdose symptoms may include severe nausea, vomiting, stomach cramps, muscle weakness or spasm, watery eyes, drooling, increased urination or bowel movements, sweating, slow heart rate, feeling light-headed or fainting, and seizure (convulsions).
chest pain, slow heart rate;
black, bloody, or tarry stools;
coughing up blood or vomit that looks like coffee grounds;
weakness, confusion, decreased sweating, extreme thirst, hot dry skin; or
urinating less than usual or not at all.
Less serious side effects may include:
feeling tired, dizzy, or light-headed;
nausea, vomiting, gas, loss of appetite;
weight loss; or
headache.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Before taking galantamine, tell your doctor if you are using any of the following drugs:
atropine (Donnatal, and others);
belladonna;
clidinium (Quarzan);
dicyclomine (Bentyl);
glycopyrrolate (Robinul);
hyoscyamine (Anaspaz, Cystospaz, Levsin, and others);
mepenzolate (Cantil);
methantheline (Provocholine);
methscopolamine (Pamine);
paroxetine (Paxil, Pexeva);
propantheline (Pro-Banthine); or
scopolamine (Transderm-Scop).
This list is not complete and there may be other drugs that can interact with galantamine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
See also: Razadyne ER side effects (in more detail)
Generic Name: Penciclovir
Class: Antivirals
VA Class: DE103
Molecular Formula: C10H15N5O3
CAS Number: 39809-25-1
Antiviral; acyclic purine nucleoside analog of guanine.1 2 3 5 9 10 11 12 14
Treatment of recurrent herpes labialis (oral and perioral herpes, cold sores, fever blisters) in adults.1 2 6 7 8 20
Efficacy not established in immunocompromised patients or children.1 20
Appy topically to lesions of the lips and surrounding skin as a 1% cream.1 2 7 12 21
Do not apply in or near the eyes since irritation may occur.1 Application to mucous membranes not recommended.1
Rub 1% cream gently into the affected area every 2 hours while awake (about 9, but at least 6, times daily) for 4 days.1 2 12 Use sufficient quantity to adequately cover all lesions of the lips and surrounding skin.21
Initiate at the earliest sign or symptom (i.e., within 1 hour of the prodrome or appearance of the first lesion) of herpes labialis.1 2 12
Hypersensitivity to penciclovir or any ingredient in the formulation.1
Category B.1
Not known whether distributed into human milk after topical application.1 Penciclovir is distributed into milk in rats following oral administration of famciclovir (the oral prodrug of penciclovir).1 Discontinue nursing or the drug.1
Safety and efficacy not established in children <18 years of age.1
Adverse effects profile in adults ≥65 years of age is similar to that in younger adults.1
Headache.1
Not appreciably absorbed into systemic circulation following topical application to the skin.1 2 5 7 12
Not detected in plasma or urine of adults following single or repeated application of 1% penciclovir cream at a dosage of 180 mg daily (about 67 times the estimated usual topical dosage).1 2 5 7 12 Systemic absorption not evaluated in children <18 years of age.1
Converted in vivo to the pharmacologically active triphosphate metabolite.1 2 5 7 9 10 11 12 13 14
20°–25°C.1
Converted in vivo to the pharmacologically active triphosphate metabolite.1 2 5 7 9 10 11 12 13 14
Exerts its antiviral effect by interfering with DNA synthesis and inhibiting viral replication.1 2 3 9 12
Active against various Herpesviridae,1 2 5 7 9 10 11 12 13 14 including herpes simplex virus types 1 and 2 (HSV-1 and HSV-2),1 2 3 5 10 12 14 varicella-zoster virus (VZV),2 5 10 12 13 14 and Epstein-Barr virus (EBV).5 9 10 11 Only limited activity in vitro against cytomegalovirus (CMV).5 11
In vitro, penciclovir triphosphate is 10–20 times more stable than acyclovir triphosphate within HSV-infected cells, resulting in more prolonged antiviral activity.2 5 8 9 14
Resistance to penciclovir reported in HSV and VZV.1 4 5 8 12 14 15
Most (but not all) acyclovir-resistant HSV and VZV are cross-resistant to penciclovir.1 4 5 8 12 13 14 15
Importance of avoiding contact with eyes.1 If contact with the eye(s) occurs, the affected eye(s) should be washed with large amounts of water; patients should consult a clinician if ocular irritation persists.
Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs.1
Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.1
Importance of advising patients of other important precautionary information. (See Cautions.)
Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.
Routes | Dosage Forms | Strengths | Brand Names | Manufacturer |
|---|---|---|---|---|
Topical | Cream | 1% | Denavir (with propylene glycol) | Novartis |
This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 03/2011. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.
Denavir 1% Cream (NEW AMERICAN THERAPEUTICS): 1/$95.99 or 4/$275.97
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions September 2005. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.
1. Novartis. Denavir (penciclovir) topical cream 1% prescribing information. East Hanover, NJ; 2001 Jan.
2. Spruance SL, Rea TL, Thoming C et al. Penciclovir cream for the treatment of herpes simplex labialis. JAMA. 1997; 277:1374-79. [IDIS 384117] [PubMed 9134943]
3. Wiltink EH. New promising antiviral drugs. Drugs of Today. 1995; 31:273-82.
4. Chatis PA, Crumpacker CS. Resistance of herpesviruses to antiviral drugs. Antimicrob Agents Chemother. 1992; 36:1589-95. [IDIS 299816] [PubMed 1416838]
5. Alrabiah FA, Sacks SL. New antiherpesvirus agents. Drugs. 1996; 52:17-32. [PubMed 8799682]
6. Ackerman B (SmithKline Beecham, Philadelphia, PA): Personal communication; 1997 July 10.
7. Raborn GW for the Penciclovir Topical Collaborative Study Group. Penciclovir cream for recurrent herpes simplex labialis: an effective new treatment. Proceedings of ICAAC New Orleans 1996. Abstract No. H81.
8. Boyd MR, Safrin S, Kern ER. Penciclovir: a review of its spectrum of activity, selectivity and cross-resistance patterns. Antiviral Chem Chemother. 1993; 4(Suppl 1): 3-11.
9. Bacon TH, Boyd MR. Activity of penciclovir against Epstein-Barr virus. Antimicrob Agents Chemother. 1995; 39:1599-1602. [IDIS 350501] [PubMed 7492112]
10. Gnann JW Jr. New antivirals with activity against varicella-zoster virus. Ann Neurol. 1994; 34:S69-72.
11. Kulikowski T. Structure-activity relationships and conformational features of antiherpetic pyrimidine and purine nucleoside analogues: a review. Pharm World Sci. 1994; 16:127-138. [IDIS 331981] [PubMed 8032338]
12. Anon. Topical penciclovir for herpes labialis. Med Lett Drugs Ther. 1997; 39:57-8. [PubMed 9205430]
13. Hasegawa T, Kurokawa M, Yukawa TA et al. Inhibitory action of acyclovir (ACV) and penciclovir (PCV) on plaque formation and partial cross-resistance of ACV-resistant varicella-zoster virus to PCV. Antiviral Res. 1995; 27:271-9. [PubMed 8540749]
14. Safrin S, Phan L. In vitro activity of penciclovir against clinical isolates of acyclovir-resistant and foscarnet-resistant herpes simplex virus. Antimicrob Agents Chemother. 1993; 37:2241-3. [IDIS 320621] [PubMed 8257152]
15. Talarico CL, Phelps WC, Biron KK. Analysis of the thymidine kinase genes from acyclovir-resistant mutants of varicella-zoster virus isolated from patients with AIDS. J Virol. 1993; 67:1024-33. [PubMed 8380452]
16. Centers for Disease Control and Prevention. 1993 Sexually transmitted diseases guidelines. 1993; 42(Suppl RR-14):22-5.
17. Shaw M, King M, Best JM et al. Failure of acyclovir cream in treatment of recurrent herpes labialis. BMJ. 1985; 291:7-9. [IDIS 202407] [PubMed 3926067]
18. Spruance SL, Crumpacker CS, Schnipper LE et al. Early, patient-initiated treatment of herpes labialis with topical 10% acyclovir. Antimicrob Agents Chemother. 1984; 25: 553-5. [IDIS 185372] [PubMed 6732224]
19. Spruance SL, Schnipper LE, Overall JC et al. Treatment of herpes simplex labialis with topical acyclovir in polyethylene glycol. J Infect Dis. 1982; 146:85-90. [IDIS 153489] [PubMed 7045255]
20. FDA summary basis of approval.
21. SmithKline Beecham, Philadelphia, PA: Personal communication.
Prednizolons may be available in the countries listed below.
Prednisolone is reported as an ingredient of Prednizolons in the following countries:
International Drug Name Search
Digoxina Lafedar may be available in the countries listed below.
Digoxin is reported as an ingredient of Digoxina Lafedar in the following countries:
International Drug Name Search
Acido Borico Farve may be available in the countries listed below.
Boric Acid is reported as an ingredient of Acido Borico Farve in the following countries:
International Drug Name Search
Oradol may be available in the countries listed below.
Domiphen Bromide is reported as an ingredient of Oradol in the following countries:
Ketorolac is reported as an ingredient of Oradol in the following countries:
Ketorolac tromethamine (a derivative of Ketorolac) is reported as an ingredient of Oradol in the following countries:
International Drug Name Search
Amoxiclav Sandoz may be available in the countries listed below.
Amoxicillin trihydrate (a derivative of Amoxicillin) is reported as an ingredient of Amoxiclav Sandoz in the following countries:
Clavulanic Acid potassium (a derivative of Clavulanic Acid) is reported as an ingredient of Amoxiclav Sandoz in the following countries:
International Drug Name Search
Treating symptoms of irritable bowel syndrome. It may also be used for other conditions as determined by your doctor.
Dicyclomine is an anticholinergic. It works by blocking a chemical in the smooth muscle of the stomach and intestines, causing them to relax, which reduces cramping.
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with Dicyclomine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
Some MEDICINES MAY INTERACT with Dicyclomine. Tell your health care provider if you are taking any other medicines, especially any of the following:
This may not be a complete list of all interactions that may occur. Ask your health care provider if Dicyclomine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Use Dicyclomine as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Dicyclomine.
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Blurred vision; constipation; decreased sweating; difficulty sleeping; dizziness; drowsiness; dry mouth; headache; lightheadedness; loss of taste; nausea; nervousness.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; confusion; diarrhea; difficulty focusing your eyes; difficulty moving; difficulty speaking; difficulty urinating; disorientation; exaggerated sense of well-being; fainting; hallucinations; pounding in the chest; rapid heartbeat; short-term memory loss; unusual weakness; vomiting.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
See also: Dicyclomine side effects (in more detail)
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; convulsions (seizures); difficulty breathing; dilated pupils; disorientation; excessive thirst; flushed, hot, dry skin; hallucinations or unusual behavior; muscle weakness; nausea; rapid heartbeat and breathing; restlessness; unusual dizziness or drowsiness; unusually dry mouth; vomiting.
Store Dicyclomine at room temperature, below 86 degrees F (30 degrees C). Protect from freezing. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Dicyclomine out of the reach of children and away from pets.
This information is a summary only. It does not contain all information about Dicyclomine. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Tarmin may be available in the countries listed below.
Loperamide hydrochloride (a derivative of Loperamide) is reported as an ingredient of Tarmin in the following countries:
International Drug Name Search
Generic Name: lenalidomide (Oral route)
len-a-LID-oh-mide
Lenalidomide may cause human birth defects, hematological toxicity (neutropenia and thrombocytopenia), deep vein thrombosis (DVT), and pulmonary embolism (PE). Lenalidomide is an analogue of thalidomide, a known human teratogen that causes severe life-threatening human birth defects. If taken during pregnancy, lenalidomide may cause birth defects or death to an unborn baby. Avoid pregnancy due to potential toxicity and to avoid fetal exposure. Lenalidomide is only available under a special restricted distribution program called RevAssist(R). Lenalidomide is associated with significant neutropenia and thrombocytopenia in patients with del 5q myelodysplastic syndromes. CBC should be monitored weekly for the first 8 weeks of therapy and at least monthly thereafter. Patients may require dose interruption and/or reduction and the use of blood product support and/or growth factors. There is an increased risk of DVT and PE in patients with multiple myeloma who receive lenalidomide. Observe patients for signs and symptoms of thromboembolism .
In the U.S.
Available Dosage Forms:
Therapeutic Class: Immune Modulator
Lenalidomide is used to treat anemia (low red blood cells) in patients with a certain type of myelodysplastic syndrome (MDS) called 5q MDS. Patients with this type of MDS may have very low red blood cell counts and require blood transfusions.
Lenalidomide is also used in combination with dexamathasone to treat multiple myeloma (plasma cell cancer) in patients who have received at least one prior therapy.
This medicine is available only under a special restricted distribution program called RevAssist® program.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, lenalidomide is used in certain patients with the following medical condition:
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of lenalidomide in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of lenalidomide in the elderly.
| Pregnancy Category | Explanation | |
|---|---|---|
| All Trimesters | X | Studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit. |
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Also, do not stop taking this medicine without checking with your doctor first.
It is very important that you understand the requirements of the RevAssist® program, and become familiar with the RevAssist® educational materials and Patient Medication Guide. Direct any questions to your doctor or pharmacist before starting lenalidomide therapy. .
You should take the necessary precautions to avoid pregnancy while taking lenalidomide. Use one highly effective form of birth control plus an additional effective form of birth control at the same time, if abstinence is not the chosen method. Begin this 4 weeks before starting lenalidomide and continue it for 4 weeks after stopping the medication.
There is a telephone survey and patient registry that you must participate in while taking lenalidomide. Ask your doctor or pharmacist if you have any questions about what you need to do.
Swallow the capsule whole, do not break, chew, or open it.
It is important that you have blood tests at regular intervals. Keep all appointments with your doctor for the tests.
It is important that you have pregnancy tests at regular intervals.
Male patients, even those who have had a vasectomy, must use a latex condom during sexual contact with a female patient.
Male patients: Do not donate semen or sperm while taking lenalidomide.
Do not donate blood while taking lenalidomide.
You should not share this medication with anyone, even if someone else has similar symptoms.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
It is very important that your doctor check your progress closely while you are using this medicine to see if it is working properly and to allow for a change in the dose. Blood tests may be needed to check for any unwanted effects.
Your doctor will want to see you every 4 weeks for pregnancy tests if you have a regular menstrual cycle, and every 2 weeks if you have an irregular cycle.
Call your doctor or 1-888-688-2528 for emergency contraception information if you think you are pregnant or, for males, if you think that your sexual partner may be pregnant.
Seek medical attention if you develop any shortness of breath, chest pain, or arm or leg swelling.
Do not breastfeed while you are using this medicine.
This medicine lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.
Serious skin reactions can occur with this medicine. Check with your doctor right away if you have blistering, peeling, or loosening of the skin; red skin lesions; severe acne or skin rash; sores or ulcers on the skin; or fever or chills while you are using this medicine.
Lenalidomide may cause a serious type of reaction called tumor lysis syndrome. Your doctor may give you a medicine to help prevent this. Call your doctor right away if you have a decrease or change in urine amount; joint pain, stiffness, or swelling; lower back, side, or stomach pain; a rapid weight gain; swelling of the feet or lower legs; or unusual tiredness or weakness.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Revlimid side effects (in more detail)
The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.
The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.
Generic Name: acetaminophen, dexbrompheniramine, and pseudoephedrine (a SEET a MIN oh fen, dex brom fen EER a meen, and soo doe e FED rin)
Brand Names: Drixoral Allergy Sinus, Drixoral Cold and Flu, Drixoral Sinus
Acetaminophen is a pain reliever and fever reducer.
Dexbrompheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.
Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).
The combination of acetaminophen, dexbrompheniramine, and pseudoephedrine is used to treat headache, fever, body aches, runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.
Acetaminophen, dexbrompheniramine, and pseudoephedrine may also be used for purposes not listed in this medication guide.
Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:
liver disease, cirrhosis, or a history of alcoholism;
a blockage in your digestive tract (stomach or intestines);
diabetes;
kidney disease;
epilepsy or other seizure disorder;
cough with mucus, or cough caused by smoking, emphysema, or chronic bronchitis;
enlarged prostate or urination problems;
low blood pressure;
pheochromocytoma (an adrenal gland tumor); or
if you take potassium (Cytra, Epiklor, K-Lyte, K-Phos, Kaon, Klor-Con, Polycitra, Urocit-K).
Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. This medicine is usually taken only for a short time until your symptoms clear up.
Do not take for longer than 7 days in a row. Stop taking the medicine and call your doctor if you still have a fever after 3 days of use, you still have pain after 7 days (or 5 days if treating a child), if your symptoms get worse, or if you have a skin rash, ongoing headache, or any redness or swelling.
Since this medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.
Overdose symptoms may also include severe forms of some of the side effects listed in this medication guide.
chest pain, rapid pulse, fast or uneven heart rate;
confusion, hallucinations, severe nervousness;
tremor, seizure (convulsions);
easy bruising or bleeding, unusual weakness;
urinating less than usual or not at all;
nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of your skin or eyes); or
dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, chest pain, shortness of breath, uneven heartbeats, seizure).
Less serious side effects may include:
dizziness, drowsiness;
mild headache;
dry mouth, nose, or throat;
constipation;
blurred vision;
feeling nervous; or
sleep problems (insomnia);
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Tell your doctor about all other medicines you use, especially:
leflunomide (Arava);
topiramate (Topamax);
zonisamide (Zonegran);
an antibiotic, antifungal medicine, sulfa drug, or tuberculosis medicine;
an antidepressant;
birth control pills or hormone replacement therapy;
bladder or urinary medications;
blood pressure medication;
a bronchodilator;
cancer medicine;
cholesterol-lowering medications such as Lipitor, Niaspan, Zocor, Vytorin, and others;
gout or arthritis medications (including gold injections);
HIV/AIDS medication;
medication for nausea and vomiting, stomach ulcers, or irritable bowel syndrome;
medicines to treat psychiatric disorders;
an NSAID such as Advil, Aleve, Arthrotec, Cataflam, Celebrex, Indocin, Motrin, Naprosyn, Treximet, Voltaren, others; or
seizure medication.
This list is not complete and other drugs may interact with acetaminophen, dexbrompheniramine, and pseudoephedrine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Picato is a brand name of ingenol mebutate topical, approved by the FDA in the following formulation(s):
No. There is currently no therapeutically equivalent version of Picato available.
Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Picato. These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication.
See also: About generic drugs.
There are no current U.S. patents associated with Picato.
Exclusivity is exclusive marketing rights granted by the FDA upon approval of a drug and can run concurrently with a patent or not. Exclusivity is a statutory provision and is granted to an NDA applicant if statutory requirements are met.
